Inhibition of p42/p44 mitogen-activated protein kinase by oxysterols in rat astrocyte primary cultures and C6 glioma cell lines

1998 ◽  
Vol 53 (1) ◽  
pp. 38-50 ◽  
Author(s):  
Monika Adamczyk ◽  
Elisabeth Scherrer ◽  
Alexandre Kupferberg ◽  
Anant N. Malviya ◽  
Marcel Mersel
Keyword(s):  
Protein Kinase ◽  
Cell Lines ◽  
Glioma Cell ◽  
Primary Cultures ◽  
C6 Glioma ◽  
Mitogen Activated Protein Kinase ◽  
C6 Glioma Cell ◽  
Glioma Cell Lines ◽  
Mitogen Activated Protein ◽  
Rat Astrocyte

scholarly journals Estradiol Receptors Regulate Differential Connexin 43 Expression in F98 and C6 Glioma Cell Lines

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0150007 ◽  
Author(s):  
Zahra Moinfar ◽  
Hannes Dambach ◽  
Bodo Schoenebeck ◽  
Eckart Förster ◽  
Nora Prochnow ◽  
...  
Keyword(s):  
Cell Lines ◽  
Connexin 43 ◽  
Glioma Cell ◽  
C6 Glioma ◽  
C6 Glioma Cell ◽  
Estradiol Receptors ◽  
Glioma Cell Lines

Ursolic acid derivatives from Bangladeshi medicinal plant, Saurauja roxburghii: Isolation and cytotoxic activity against A431 and C6 glioma cell lines

2011 ◽  
Vol 4 (3) ◽  
pp. 287-291 ◽  
Author(s):  
Kishor Mazumder ◽  
Eric R.O. Siwu ◽  
Satoshi Nozaki ◽  
Yasuyoshi Watanabe ◽  
Katsunori Tanaka ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Ursolic Acid ◽  
Glioma Cell ◽  
C6 Glioma ◽  
C6 Glioma Cell ◽  
Glioma Cell Lines

A viscochromic, mechanochromic, and unsymmetrical azine for selective detection of Al3+ and Cu2+ ions and its mitotracking studies

2019 ◽  
Vol 43 (18) ◽  
pp. 7109-7119 ◽  
Author(s):  
Richa Yadav ◽  
Abhishek Rai ◽  
Avinash Kumar Sonkar ◽  
Vipin Rai ◽  
Subash Chandra Gupta ◽  
...  
Keyword(s):  
Cell Lines ◽  
Glioma Cell ◽  
C6 Glioma ◽  
Selective Detection ◽  
C6 Glioma Cell ◽  
Glioma Cell Lines

A mechanoresponsive, viscochromic, and unsymmetrical azine NDEA probes Al3+ and Cu2+ ions and also co-localizes in the mitochondria of C6 glioma cell lines.

scholarly journals Synthesis of dihydropyrimidin-2-one/thione library and cytotoxic activity against the human U138-MG and Rat C6 glioma cell lines

2011 ◽  
Vol 22 (7) ◽  
pp. 1379-1388 ◽  
Author(s):  
Rômulo F. S Canto ◽  
Andressa Bernardi ◽  
Ana Maria O Battastini ◽  
Dennis Russowsky ◽  
Vera Lucia Eifler-Lima
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Glioma Cell ◽  
C6 Glioma ◽  
C6 Glioma Cell ◽  
Glioma Cell Lines ◽  
Rat C6 Glioma

scholarly journals Thymosin Fraction 5 Inhibits the Proliferation of the Rat Neuroendocrine MMQ Pituitary Adenoma and C6 Glioma Cell Lines in Vitro*

Endocrinology ◽  
1998 ◽  
Vol 139 (4) ◽  
pp. 2155-2162 ◽  
Author(s):  
Bryan L. Spangelo ◽  
Derald D. Farrimond ◽  
Mahesh Thapa ◽  
Charles M. Bulathsinghala ◽  
Kay-Lynn Bowman ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Cell Lines ◽  
Glioma Cell ◽  
C6 Glioma ◽  
C6 Glioma Cell ◽  
Glioma Cell Lines

Staurosporine and its derivative RO31-8220, both inhibitors of protein kinase C, have different effects on C6 glioma cell morphology

1993 ◽  
Vol 21 (4) ◽  
pp. 381S-381S ◽  
Author(s):  
Helen J. M. Thompson ◽  
Barbara S. Mallon ◽  
Gary J. Litherland ◽  
Martin G. Rumsby
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cell Morphology ◽  
Glioma Cell ◽  
C6 Glioma ◽  
C6 Glioma Cell ◽  
Kinase C

scholarly journals MicroRNA-132 Plays an Independent Prognostic Role in Pancreatic Ductal Adenocarcinoma and Acts as a Tumor Suppressor

2019 ◽  
Vol 18 ◽  
pp. 153303381882431 ◽  
Author(s):  
Yan Chen ◽  
Huiyun Zhu ◽  
Yuqiong Wang ◽  
Yingxiao Song ◽  
Pingping Zhang ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Protein Kinase ◽  
Prognostic Factor ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Cell Lines ◽  
Mitogen Activated Protein Kinase ◽  
Ductal Adenocarcinoma ◽  
Adenocarcinoma Cell ◽  
Nuclear Transcription Factor ◽  
Mitogen Activated Protein

The role of microRNA-132 in human pancreatic ductal adenocarcinomas is still ambiguous. We explored the association between microRNA-132 and pancreatic ductal adenocarcinoma prognosis. The expression of microRNA-132 in 50 pancreatic ductal adenocarcinoma tissue samples and pancreatic ductal adenocarcinoma cell lines was examined, and the association between its expression and pancreatic ductal adenocarcinoma prognosis was assessed. Functional analysis and factors downstream of microRNA-132 were investigated. Kaplan-Meier survival curves showed that high expression of microRNA-132 was a significant prognostic factor for 1-year survival of patients with pancreatic ductal adenocarcinoma ( P = .028). Multivariate analysis for overall survival indicated that high expression of microRNA-132 was an independent prognostic factor for patients with pancreatic ductal adenocarcinoma ( P = .044). Low expression of microRNA-132 was associated with poor prognosis in pancreatic ductal adenocarcinoma. Ectopic expression of microRNA-132 significantly inhibited proliferation and promoted apoptosis of 2 pancreatic ductal adenocarcinoma cell lines. Bioinformatic analysis revealed that microRNA-132 may exert its effects on pancreatic ductal adenocarcinoma through downregulating mitogen-activated protein kinase 3 and nuclear transcription factor Y subunit α. The results of this study further our understanding of the relationship between microRNA-132 and pancreatic ductal adenocarcinoma by showing that microRNA-132 might inhibit the progression of pancreatic ductal adenocarcinoma by regulating mitogen-activated protein kinase and nuclear transcription factor Y subunit alpha.

scholarly journals Neuroprotective potential of isothiocyanates in an in vitro model of neuroinflammation

2020 ◽  
Author(s):  
Tiziana Latronico ◽  
Marilena Larocca ◽  
Serafina Milella ◽  
Anna Fasano ◽  
Rocco Rossano ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Neurological Diseases ◽  
Primary Cultures ◽  
Allyl Isothiocyanate ◽  
Mapk Signaling ◽  
Mitogen Activated Protein Kinase ◽  
Pcr Analysis ◽  
Ros Production ◽  
Mitogen Activated Protein

AbstractIsothiocyanates (ITCs), present as glucosinolate precursors in cruciferous vegetables, have shown anti-inflammatory, antioxidant and anticarcinogenic activities. Here, we compared the effects of three different ITCs on ROS production and on the expression of matrix metalloproteinase (MMP)-2 and -9, which represent important pathogenetic factors of various neurological diseases. Primary cultures of rat astrocytes were activated by LPS and simultaneously treated with different doses of Allyl isothiocyanate (AITC), 2-Phenethyl isothiocyanate (PEITC) and 2-Sulforaphane (SFN). Results showed that SFN and PEITC were able to counteract ROS production induced by H2O2. The zymographic analysis of cell culture supernatants evidenced that PEITC and SFN were the most effective inhibitors of MMP-9, whereas, only SFN significantly inhibited MMP-2 activity. PCR analysis showed that all the ITCs used significantly inhibited both MMP-2 and MMP-9 expression. The investigation on the mitogen-activated protein kinase (MAPK) signaling pathway demonstrated that ITCs modulate MMP transcription by inhibition of extracellular-regulated protein kinase (ERK) activity. Results of this study suggest that ITCs could be promising nutraceutical agents for the prevention and complementary treatment of neurological diseases associated with MMP involvement.

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